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July 21–23, 2021 | Virtual

Extracellular vesicle studies

From benchtop to therapeutics

Extracellular vesicle studies: From benchtop to therapeutics
July 21–23, 2021 | Virtual

Extracellular vesicles are secreted, membrane-bound compartments containing DNA and cytoplasmic constituent molecules of all types that are thought to act as mediators of intercellular communication. They are classified by both size and location/mechanism of cellular origination. They are thought to be produced by an ever-expanding diversity of cell types and species. However, there is also considerable skepticism related to their existence and utility, as it can be difficult to isolate EVs since there is no EV-specific molecular marker to target.

A primary focus in recent years has been to describe the mechanisms of molecular sorting that would allow researchers to target proteins produced from exogenously introduced DNA to EVs for cellular secretion and uptake. The potential value of EVs to therapeutics is thought to be enormous, thanks to the role of EVs in cell–cell communication as a robust, native delivery vehicle.

This event will appeal to a broad audience, including molecular biologists, biochemists, biophysicists, secretion experts, cell–cell communication specialists, clinicians, physiologists and others.

Important dates

July 16
11:59 p.m. Eastern
Registration deadline

Sponsors

Organizers

Michael Wells

Idaho College of Osteopathic Medicine
Kenneth W. Witwer

Johns Hopkins University School of Medicine

Speakers

Jennifer Jones

Center for Cancer Research, National Cancer Institute
Jason Shepherd

University of Utah
Joy Wolfram

Mayo Clinic
Masako Harada

Michigan State University
Steven Jay

University of Maryland
Randy Schekman

University of California, Berkeley

Virtual event

Precious cargo?

In this Q&A, one of the meeting organizers urges the BMB community to interrogate the potential of enigmatic extracellular vesicles

Program schedule

All times listed are U.S. Eastern Daylight Time (GMT-4)

Wednesday July 21
Thursday July 22
Friday July 23

Wednesday agenda

10:00 AM - 11:00 AM

Poster presentations

11:00 AM - 11:40 AM

Keynote speaker

Virus-like biogenesis of extracellular vesicles
Jason Shephard, University of Utah School of Medicine

11:40 AM - 12:00 PM

Vendor demos

12:00 PM - 1:00 PM

Plenary session 1: Starting from scratch

A new infectious unit: Extracellular vesicles carrying virus populations
Nihal Altan–Bonnet, National Institutes of Health
Mitochondrial-derived extracellular vesicle biogenesis is regulated by RAB7: insights from chemoresistance
Flora Guerra, University of Salento
Transfer of Cas9 for genome editing via intercellular tubular connection
Randy Schekman, University of California, Berkeley
1:10 PM - 2:10 PM

Plenary session 2: Back to basics

Leishmania-infected macrophages release extracellular vesicles that activate endothelial cell processes and may promote vascularization of Leishmania lesions
Anna Gioseffi, University of Florida
Tumor microvesicles: biogenesis and biology
Crislyn D'Souza–Schorey, University of Notre Dame
Antigen-encapsulating exosomes from Salmonella-infected macrophages stimulate pathogen-specific Th1-type responses in vivo
Mariola Edelman, University of Florida
2:10 PM - 3:00 PM

Panel discussion: Individual EV uniqueness and ramifications

3:00 PM - 4:00 PM

Poster presentations

Thursday agenda

10:00 AM - 11:00 AM

Poster presentations

11:00 AM - 11:40 AM

Keynote speaker

EVs, exosomes, and liquid biopsies: Can we improve data clarity with structure?
Jennifer Jones, National Institutes of Health
11:40 AM - 12:00 PM

Vendor demos

12:00 PM - 1:00 PM

Plenary session 3: Sources of EVs: opportunities and challenges (part 1)

ISEV rigor and reproducibility intro
Juan Manuel Falcon Perez, CIC bioGUNE
Blood plasma/serum/flow
Rienk Nieuwland, University of Amsterdam Medical Center
Urine
Uta Erdbruegger, University of Virginia School of Medicine
1:10 PM - 2:10 PM

Plenary session 4: Sources of EVs: opportunities and challenges (part 2)

Solid tissue
Tanina Arab and Yiyao Huang, Johns Hopkins University
CSF
Julie Saugstad Ursula Sandau, Oregon Health & Science University
Cell culture media
Faezeh Shekari, Royan Institute
2:10 PM - 3:00 PM

Panel discussion: How to best control for a human EV experiment: methods, markers and analysis

3:00 PM - 4:00 PM

Poster presentations

Friday agenda

10:00 AM - 11:00 AM

Poster presentations

11:00 AM - 11:40 AM

Keynote speaker

Extracellular vesicle therapeutics: from past to present
Joy Wolfram, Mayo Clinic Nanomedicine and Extracellular Vesicles Laboratory
11:40 AM - 12:00 PM

Vendor demos

12:00 PM - 1:00 PM

Plenary session 5: Special delivery

Exploiting exosomes as a strategy to treat neuronopathic lysosomal storage disorders
John Santelices, University of Florida
Study of the characterization and therapeutic effect of fluorescent anti-fibrotic extracellular vesicles
Jorge Ruiz del Rio, University of Cantabria
Exosome-based delivery system to prevent drug resistance to BRAF/MEK inhibitors by restoring the activity of channel protein Cx43 in BRAF-driven tumours
Adrián Varela–Vázquez, Galician Healthcare Service
1:10 PM - 2:10 PM

Plenary session 6: Carrying precious cargoes

Engineered gectosomes for delivering intracellular biologics
Xuedong Liu, University of Colorado Boulder
Engineered extracellular vesicles for targeted therapeutic delivery
Masako Harada, Michigan State University
Therapeutic potential of extracellular vesicle-associated long non-coding RNA
Steven Jay, University of Maryland
2:10 PM - 3:00 PM

Panel discussion: Needs of the field and future directions

3:00 PM - 4:00 PM

Poster presentations

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