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Motifs, modules, networks: Assembly and organization of regulatory signaling systems

July 11–14, 2023
Bolger Center, Potomac, Md.

Our understanding of how cellular signaling networks are organized has evolved substantially in recent years. Namely, the myriad components of signaling networks — receptors, signaling enzymes such as phosphatases and kinases, substrates and scaffolding proteins — often assemble through highly dynamic interactions involving intrinsically disordered regions and short linear sequence motifs (SLiMs). These dynamic interactions allow for rapid responses to signaling inputs and dictate systems-level properties of signaling networks. Understanding SLiM-mediated interactions has made it possible to define “substratomes” of signaling enzymes as well as interaction networks that provide novel insights into signaling platforms and cellular networking mechanisms.

This interdisciplinary conference will bring together researchers in structural biology, biochemistry, computational biology and proteomics who investigate cellular signaling networks and leverage these insights into the development of new therapeutic strategies.

Learn more

Cellular signaling networks in JBC

A specially curated collection of articles published in the Journal of Biological Chemistry in recent years showcasing the latest breakthroughs in cellular signaling networks.

Organizers

Wolfgang Peti

UConn Health
Arminja Kettenbach

Dartmouth Geisel School of Medicine
Benjamin Turk

Yale School of Medicine

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Sponsors

Important dates

May 15 Early registration deadline*
May 31 Abstract submission deadline for oral and poster (authors are required to register for the conference upon submission of abstract)
June 12 Deadline for cancelations/refunds (no refunds after this date)
June 12 Regular registration deadline*

*Registration and housing are on a first-come, first-served basis and will remain open until capacity is reached. This may mean that the conference registration closes before the officially posted registration deadline. To secure your spot at the conference we encourage you to register early.

Conference information

  • Conference will begin around 4 p.m. on July 11.
  • Conference will conclude around 2 p.m. on July 14.

Registration and abstracts

  • There is no onsite registration, all attendees must be registered prior to arriving at the conference.
  • Registration for the conference is required at the time of abstract submission.
  • Please reach out to meetings@asbmb.org if you have questions.

Health and safety

  • Mask-wearing and other health and safety measures will be determined based on local, state and venue guidelines and will be communicated to attendees prior to the conference.

Getting to the Bolger Center

Airports

  • (DCA) — 19.6 miles
  • (IAD) — 24.5 miles
  • (BWI) — 39.8 miles

Getting from the airports to the Bolger Center

All attendees are responsible for their own transportation. There will not be a shuttle provided to/from the airports/.

  • Uber/Lyft/Rideshare
  • Closest metro station is — 5.5 miles away from Bolger Center.

Visas

All individuals traveling from outside of the United States should apply for a visa as soon as possible and at least four to five months prior to their date of travel.

  • The most up-to-date information about traveling to the U.S. can be found at the .
  • Scientists visiting the U.S. may find helpful information at the .
  • .

Please do not wait until you receive your registration confirmation before applying for a visa. We encourage you to apply for your visa right away if you are considering attending to avoid delays and longer than anticipated wait times.

All visitors traveling to the U.S. from  must meet all requirements of the program. .


Program schedule

Tuesday July 11
Wednesday July 12
Thursday July 13
Friday July 14

Tuesday agenda

4:00 PM - 7:00 PM

Badge pickup

5:30 PM - 7:00 PM

Dinner

7:00 PM - 7:15 PM

Welcome and opening remarks by the organizers

7:15 PM - 8:45 PM

Session I: New approaches to short linear motif discovery

Session chair: Wolfgang Peti

Exploring mutational effects in phosphotyrosine signaling using bacterial peptide display
Neel Shah, Columbia University
The intrinsic substrate specificity of the human protein tyrosine kinome
Jared Johnson, Dana–Farber Cancer Institute
Peptide-based interactomics of the claudin family identifies a linear motif that recruits the proteasome to the tight junctions
Gunnar Ditmar, Luxembourg Institute of Health
9:00 PM - 10:30 PM

Pony Express discussions

Wednesday agenda

6:00 AM - 9:00 AM

Breakfast

7:30 AM - 12:00 PM

Badge pickup

8:30 AM - 11:45 AM

Session II: Biophysics of linear motif function

Session chair: Rebecca Page

Includes coffee break at 10 a.m.

Interaction specificity of EVH1 domains with short linear motifs
Amy Keating, Massachusetts Institute of Technology
Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP and Dok1
Kimberly Vish, Yale University
Autoregulation of ZNF410 DNA binding by a DNA-mimicking protein loop
Gundeep Kaur, University of Texas MD Anderson Cancer Center
Distribution of SLiMs in the quasispecies of SARS-CoV-2 nucleocapsid protein intrinsically disordered regions
Peter Schuck, National Institutes of Health
Deciphering the role of phosphorylation in disordered regulatory motifs in the kinase Wee1
Ricarda Törner, Dana–Farber Cancer Institute
A purely thermodynamic anti-prionic mode of action for protein-misfolding diseases
Dieter Willbold, Forschungszentrum Jülich
Structural insights into the activation and regulation of a unique calmodulin-activated kinase
Ranajeet Ghose, City College of New York
Expanding the sortase toolbox: Selectivity determinants of target recognition for Class B sortases
Jeanine Amacher, Western Washington University
12:15 PM - 1:30 PM

Lunch

1:30 PM - 3:30 PM

Session III: Protein interaction networks

Session chair: Arminja Kettenbach

Proximity-dependent sensors for signalling
Anne-Claude Gingras, Lunenfeld–Tanenbaum Research Institute
Proteomic analysis of immune-challenged macrophage myddosome
Joseph Gillen, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Genomic editing of human HEK-293 cells, generating lines recapitulating pathogenic variant of PPP2R5D, associated with Jordan’s Syndrome reveal altered signaling pathways that coordinated cell growth
Ashley Camp, University of South Alabama College of Medicine
An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells
Wenxue Li, Yale University School of Medicine
A domain analysis pipeline to predict the impact of post-translational modifications on protein domains
Gabrielle Martinez, University of Virginia
Systems and motif-based approaches to deciphering kinase signaling: a focus on cancer, DNA damage, and inflammation
Mike Yaffe, Massachusetts Institute of Technology
3:30 PM - 4:00 PM

Networking break

4:00 PM - 5:30 PM

Poster session I

5:30 PM - 7:00 PM

Dinner

7:00 PM - 8:30 PM

Session IV: Computational modeling of signaling networks

Session chair: Neel Shah

Identification of phenotype-specific signalling networks using a module-based bottom-up network inference approach
Evangelia Petsalaki, EMBL–European Bioinformatics Institute
Mapping the bacterial kinome atlas
Brady O'Boyle, University of Georgia
Discovery of diverse sequence motifs driving membrane protein clustering
Assaf Elazar, St. Jude Children’s Research Hospital
Towards a functional map of the intrinsically disordered proteome
Norman Davey, Institute of Cancer Research
9:00 PM - 10:00 PM

Pony Express discussions

Thursday agenda

6:00 AM - 9:00 AM

Breakfast

7:30 AM - 12:00 PM

Badge pickup

9:00 AM - 11:45 AM

Session V: Compartmentalization of cellular signaling

Session chair: Anne-Claude Gingras

Includes coffee break at 10:15 a.m.

Illuminating the biochemical activity architecture of the cell
Jin Zhang, University of California, San Diego
Exploring and exploiting the spatial constraints of cAMP signaling
John Scott, University of Washington
The vesicle trafficking adaptor Epsin-R has prion-like/phase separation properties controlled by a novel short linear motif
Ruben Aguilar, Purdue University
New insights into scaffolding by human IQGAP1, a scaffold for the MAP kinase and PI 3-kinase pathways
Lee Bardwell, University of California, Irvine
AKAP-scaffolding of PKA and calcineurin in amyloid β-mediated synaptic dysfunction
Mark Dell'Acqua, University of Colorado Anschutz Medical Campus
Sensitive fluorescent biosensor reveals differential subcellular regulation of PKC
Qi Su, University of California, San Diego
12:15 PM - 1:30 PM

Lunch

1:30 PM - 3:30 PM

Session VI: Regulation of short linear motif interactions

Session chair: Benjamin Turk

Proteome-scale mapping of binding sites in the intrinsically disordered regions
Ylva Ivarsson, Uppsala University
Disentangling sequence constraints on the cofilin N-terminal phosphorylation site
Joel Sexton, Yale University
More than the sum of its parts: A composite SLiM confers a unique mechanism of calcineurin regulation
Devin Bradburn, Stanford University
Exploring the role of alternative splicing in regulating post translational modifications and their binding motifs
Sam Crowl, University of Virginia
Cardiovirus leader proteins retarget RSK kinases toward the nuclear pore complex via two distinct short linear motifs
Belen Lizcano–Perret, de Duve Institute
SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity
Rebecca Page, University of Connecticut Health Center
3:30 PM - 4:00 PM

Networking break

4:00 PM - 5:30 PM

Poster session II

5:30 PM - 7:00 PM

Dinner

7:00 PM - 10:00 PM

Pony Express discussions

Friday agenda

6:00 AM - 9:00 AM

Breakfast

7:30 AM - 12:00 PM

Badge pickup

9:00 AM - 11:15 AM

Session VII: Control of essential biological processes by SLiM modulation

Session chair: John Scott

Includes coffee break at 10 a.m.

Autoinhibition in regulation of dynamic protein complexes: Focus on the dynein motor
Elisar Barbar, Oregon State University
Role of micro-RNA-128/195 and FQQI motif in the internalization, signaling and downregulation of membrane guanylyl cyclase-A/natriuretic peptide receptor-A
Kailash Pandey, Tulane University Health Sciences Center
Ehrlichia chaffeensis TRP120 contains a novel Wnt SLiM and HECT E3 ubiquitin ligase to mediate Hippo and Wnt signaling for intracellular survival
Caitlan Karousos, University of Texas Medical Branch at Galveston
SLiMs-derived chimeric peptide modulators of PP1 reveal mechanism of site-specific dephosphorylation and haspin as a novel substrate
Hieu Nguyen, Dartmouth College
Inhibitor-3 uses a novel dynamic SLIM-type interaction to inhibit protein Phosphatase 1
Meng Choy, UConn Health Center
A processive mechanism of proximity-induced catalysis by the protein kinase JNK ensures efficient activation of the transcription factor ATF2
Kevin Dalby, University of Texas at Austin
11:15 AM - 12:15 PM

Networking break

12:15 PM - 1:30 PM

Lunch