鶹ýɫƬ

News

Retracting publications doesn’t stop them from influencing science

“Zombie papers” keep on getting cited, with huge ripple effects
Fanni Daniella Szakal
By Fanni Daniella Szakal
March 28, 2021

What do studies on , , and have in common? The resulting scientific papers were all retracted. 

Retracting-445x297.jpg
Annie Spratt via Unsplash

Nevertheless, they have all been cited countless times since then. As an eraser of mistakes in scientific publishing, retraction discredits the validity of a study's claims due to flawed methodology, biased interpretation, or even fabrication of data. Unfortunately, it seems it is not so easy to erase a published study from the collective scientific consciousness. A retracted study should be a relic belonging to the virtual museum of past science – but like zombies of the scientific publishing world, they are kept alive by continued citations. 

A study in Science analyzed the post-retraction citations of two COVID-19 papers originally published in and in . As both studies were linked to the same dubious database as the source of their raw data, their retractions were followed by a widespread .  

Despite all the attention these studies received, researchers at Science found that they have been as support for scientific findings without mentioning their retracted status. These incorrect citations showed up in even the most prominent scientific journals, such as PLOS ONE, the Proceedings of the National Academy of Sciences, and Nature Communications. Retraction does not seem to achieve its desired effect – in fact, it seems that in the long term, retraction . 

Science is influential. Since it's used to drive medical, policy, and scientific decisions, the consequences of citing retracted studies as credible science can be dire. It is essential that both authors and publishers take care to stop citing them. 

Incorrect claims, stemming from the citation of a "zombie" paper, can ripple misinformation into many more new studies. Another looked at the citation patterns of a paper on the use of omega-3 supplementation for COPD patients which was retracted 11 years ago due to fraud. The authors found that 96% of papers citing the study did not mention its retracted status and 41% did so while even describing the study in detail. At this point, the spread of misinformation seems inevitable, as even the authors who take care not to cite retracted studies will trust the information and continue to cite these non-retracted papers that do cite a fraudulent study. 

Keeping flawed science alive can even be life-threatening – as in the case of the fraudulent studies of the infamous Joachim Boldt with tied to his name to date. He supported an intravenous therapy using hydroxyethyl starch to stabilize patients during and after surgery. In on the compound, its use was linked to higher patient mortality. Unfortunately, many of his studies are still being cited today.

As well as spreading misinformation and harming patients, flawed studies can have negative societal and policy consequences too. A published in Nature Communications suggested that female mentorship in academia had detrimental effects on the careers of female mentees and attacked current diversity policies in academia. Following outrage from both scientists and the public, the study was shortly retracted. As well as erroneously , it also disregarded gender discrimination in science. However, if retraction cannot fully discredit the study as it should, the efforts to reach greater gender equality in academia will be damaged. 

The root cause of the issue is often simple – many scientists would likely admit to having at least once copied relevant citations from another paper without reading them, just out of sheer convenience. Moreover, while the retraction notice is present on the publisher's site, it often , making the author believe that the study is valid. 

This is a major glitch in the system. We are scientists, dedicating our whole lives to painstakingly pipetting or analyzing massive databases. We should not lack the diligence to pay attention to such an important and glaring detail like whether a paper was retracted. In each and every publication, author guidelines should include that the author is needed to check all citations for possible retractions. Today numerous citation software are available to do this with ease; such as , i, and alert users for any retracted papers in the reference list. As well as more care from authors, preventing post-retraction citations is a responsibility of publishers too. Along with double-checking the reference list of papers to be published, they should also make sure that retraction notices appear on all platforms where the study is available.

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Fanni Daniella Szakal
Fanni Daniella Szakal

Fanni Daniella Szakal graduated with a B.Sc. in biology from the University of Edinburgh and went on to do an M.Sc. in marine biology at the University of Amsterdam.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in Opinions

Opinions highlights or most popular articles

At a career crossroads: Exploring postdoc, faculty and industry paths
Essay

At a career crossroads: Exploring postdoc, faculty and industry paths

Sept. 19, 2024

“At the crossroads of an academic career, postdocs find ourselves grappling with a challenging decision … about defining our trajectory in academia and shaping the impact we want to have in the academic community.”

How do you help a biochemist find a career path?
Essay

How do you help a biochemist find a career path?

Sept. 18, 2024

Industry, academia and the ASBMB join forces to introduce students job options in the sciences with a panel, networking and cheese.

'Don’t be afraid to take a different path'
Profile

'Don’t be afraid to take a different path'

Sept. 11, 2024

In 2016, MOSAIC scholar Rebecca Ann Faulkner paused her career for four years to focus on her family, a decision she believes made her a more effective and empathetic scientist.

The perverse legacy of participation in human genomic research
Essay

The perverse legacy of participation in human genomic research

Sept. 7, 2024

The story of how one person became the majority source of DNA for the Human Genome Project encapsulates 20th-century researchers’ attitudes toward donor consent, the author says.

Announcing the winners of the 鶹ýɫƬ Motifs bioart competition
Contest

Announcing the winners of the 鶹ýɫƬ Motifs bioart competition

Sept. 3, 2024

The 12 winning works of art to be featured in the 2025 ASBMB calendar were selected from 37 entries received from scientists in both academia and industry at all career stages with submissions coming from as far away as Pakistan and Brazil.

The fourth third of my career: Living the dream
Essay

The fourth third of my career: Living the dream

Aug. 28, 2024

After a few decades of being a professor, Jonathan Monroe thought it would be fun to return to the life of a postdoc after retiring. Here’s how he did it.