Cancer
Cholesterol synthesis and cancer
Researchers find that the active form of a key cholesterol synthesis enzyme is upregulated in endometrial cancer tissues.
From the journals: JBC
Lung cancer cells resist ferroptosis. ORMDL3 in ulcerative colitis. Novel genetic variants in thyroid cancer. Read about these recent papers.
Radioactive drugs strike cancer with precision
The tumor-seeking radiopharmaceuticals are charting a new course in oncology, with promise for targeted treatments with fewer side effects.
Scientists track 'doubling' in origin of cancer cells
Researchers at Johns Hopkins say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times.
From the journals: JLR
Switching cancer cells from pro- to antitumor. Species-specific skeletal muscle metabolism. Protein deletion improves metabolic disorders Read about recent papers on these topics.
'Protein sandwich' could transform cancer drug discovery
A team led by Alessio Ciulli has defined a new class of so-called 鈥渋ntramolecular bivalent glue,鈥� which binds proteins that would otherwise stay apart.
From the journals: MCP
Amino acids and sulfate signatures. Unveiling phosphatase substrates. Simplifying bacterial proteome profiling. Read about recent papers on these topics.
Focusing on a pivotal axis in chemoresistance
Answers may lie in microRNA changes at the intersection of a cell cycle鈥搑egulating protein and a transcription factor that plays various roles in cancer.
A focus on histone modifications in development and disease
Three researchers will present the Soshev group鈥檚 work at Discover BMB.