Disease mechanisms and treatments
UCLA researchers engineer experimental drug for preventing heart failure after heart attacks
This new single-dose therapy blocks a protein that increases inflammation and shows promise in enhancing muscle repair in preclinical models.
Helping mitochondria run smoothly may protect against Parkinson鈥檚 disease
As the powerhouse of the cell, mitochondria lie at the intersection of many essential biochemical pathways. When they go awry, neurodegenerative diseases can result.
A common parasite could one day deliver drugs to the brain
Bill Sullivan explains how scientists are turning Toxoplasma gondii, often found in contaminated food or cat feces, from foe into friend.
At the Salton Sea, uncovering the culprit of lung disease
Scientists have long suspected a link between the dust and poor respiratory health. According to recent findings, the prime suspect is a naturally occurring toxin.
From the Journals: JBC
Nuclear actin affects transcription elongation. Proteostasis in Alzheimer鈥檚 disease. RNA and splicing affect cancer invasiveness. Read about recent papers on these topics.
Do ribosomal traffic jams cause Huntington鈥檚 disease?
鈥淛ust because there are a lot of cars doesn鈥檛 mean they鈥檙e all reaching their destination,鈥� a researcher points out. And so it goes with mRNA translation within mitochondria.
Finding the transcriptional basis of diet-induced obesity
A recent study shows the previously unknown role of hepatic transcription factor FOXA3 in metabolic disease.
The quest to treat and cure xerostomia
Blake Warner, chief of the Salivary Disorders Unit at the NIH talks about his lab鈥檚 efforts to develop treatments for dry mouth.
Radioactive drugs strike cancer with precision
The tumor-seeking radiopharmaceuticals are charting a new course in oncology, with promise for targeted treatments with fewer side effects.