Proteins and proteomics
From the journals: JBC
Linking modified cysteines to cell migration. Recognizing protein tags for degradation. Disrupting C. difficile toxin production. Read about recent JBC papers on these topics.
Examining mechanisms of protein complex at a basic cell biological level
Mary Munson is co-corresponding author on a study revealing functions and mechanisms of the exocyst that are essential to how molecules move across a membrane through vesicles in a cell.
Breaking through limits in kinase inhibition
Paul Shapiro, the first speaker on ASBMB Breakthroughs, a new webinar series highlighting research from ASBMB journals, discussed taking ideas and discoveries from basic science research toward clinical applications.
A proteomic hunt for phosphosites in the aging brain
In older mice, researchers found more enzymes that phosphorylate other proteins and changes in phosphorylation levels in proteins associated with neurodegeneration.
From the journals: JBC
Histone demethylase inhibited by own sequence. MicroRNA reduces cell cycle鈥搑elated apoptosis. Multipurpose antibiotic takes on staph infections. Read about recent JBC papers on these topics.
When ribosomes go rogue
鈥疷nusual variations in the cellular protein factory can skew development, help cancer spread and more. But ribosome variety may also play biological roles, scientists say.
Of yeasts and men: One-hour proteomes, 10 years apart
To profile the human proteome within an hour, the researchers used a new mass spectrometer and packed their liquid chromatography columns with very high pressure.
Does a protein hold the key to Alzheimer鈥檚?
Researchers in Maryland and Massachusetts team up to study how SORL1 promotes tau trafficking and seeding in cells that leads to the neurodegenerative disorder.
MSU researchers leverage cryo-EM for decades-in-the-making breakthrough
Lee Kroos and Ben Orlando have reported the first high-resolution experimentally determined structures of the intramembrane protease SpolVFB.