麻豆传媒色情片

Award

Selenium led Zhao from icy hometown to German hospitality

Meet a JBC/Tabor award winner
Nathalie Gerassimov
Feb. 9, 2020

Wenchao Zhao is fascinated by or, more accurately, what happens when it is lacking.

The 2020 JBC Herbert Tabor Early Career Investigator Award winners will present their work at the 2021 ASBMB Annual Meeting, 1:45–3 p.m., Tuesday, April 27.

Find out about registering for the annual meeting here.

A trace element in soil, selenium is an essential nutrient for many species, including humans. Its deficiency is associated with Keshan disease, a cardiomyopathy first identified in the Keshan county of Heilongjiang province in northeastern China, bordering Russia. Zhao’s hometown is Harbin, the capital of that province, a city of more than five million people known for .

Zhao-Wenchao-300x307.jpg
Wenchao Zhao studies Keshan disease, a nutrient deficiency named for the county in northeastern China where he grew up.

Keshan disease used to be widespread in China, especially in Heilongjiang province, before the government started a selenium supplementation program in the 1970s. Research into the mechanism of selenium action in physiology remains important, not least because a form of thyroid disease is caused by mutations in the selenium pathway.

Zhao decided to study the effect of selenium deficiency using chickens when he was doing master’s degree research in his hometown. This descriptive research prompted him to seek laboratories studying the molecular mechanism of selenium action. Ulrich Schweizer’s lab at the University of Bonn’s Institute of Biology and 麻豆传媒色情片 Biology was a perfect fit, although Zhao spoke no German.

Zhao describes himself as “super lucky” to have Schweizer as his mentor. In addition to tutoring him in the lab, Schweizer helps him adapt to his unfamiliar German life. When Zhao couldn’t find an apartment right away, he lived at Schweizer’s house for his first month in Bonn.

Zhao is now writing his Ph.D. dissertation and hopes to finish his degree this spring. He doesn’t have firm post-graduation plans; learning to manipulate sequencing data from his research is a short-term goal.

When not working in the lab or playing basketball or soccer with his friends, Zhao is learning German. His favorite and most-used phrase is “Alles gut” — all is well.

Tissue-specific stability of key regulator of selenoprotein synthesis

Selenoproteins, characterized by the presence of selenocysteine, the 21st amino acid containing selenium in its sidechain, are essential to human health. Their main roles are in the antioxidative response and thyroid function. Not surprisingly, selenoprotein deficiency is associated with cancers, heart disease and neurodegeneration.

The biosynthesis of selenoproteins relies on selenocysteine insertion sequence-binding protein 2, or SECISBP2. Human mutations in SECISBP2 associate with clinical phenotypes of variable severity. Wenchao , published in the Journal of Biological Chemistry and selected for the Journal of Biological Chemistry/Herbert Tabor Early Career Investigator Award, investigated the effect of two human mutations using mice.

Zhao and his colleagues found that while one mutation behaves like a null allele, the other shows a different phenotype in the liver and the brain. Specifically, the R543Q mutant of the SECISBP2 protein is unstable and undetectable in liver but retains residual function in brain.

Zhao’s research contributes to our understanding of why so many diseases of ubiquitous proteins affect specific organs, he said. “A mutation may not be equally detrimental in every cellular context, since cellular context can affect the stability of that protein.”

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Nathalie Gerassimov

Nathalie Gerassimov is a postdoctoral researcher at the Carnegie Institution of Washington department of embryology.

Get the latest from ASBMB Today

Enter your email address, and we鈥檒l send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Honors for Bhatt, Lim and Nuñez
Member News

Honors for Bhatt, Lim and Nuñez

Sept. 16, 2024

Ami Bhatt receives the American Society of Hematology's William Dameshek Prize. The Pew Charitable Trusts selects Ci Ji Lim and James Nuñez as 2024 Pew scholars.

In memoriam: Robert Warren Newburgh
In Memoriam

In memoriam: Robert Warren Newburgh

Sept. 16, 2024

He was a distinguished developmental and cell biologist and a member of the ASBMB since 1957.

'Don鈥檛 be afraid to take a different path'
Profile

'Don鈥檛 be afraid to take a different path'

Sept. 11, 2024

In 2016, MOSAIC scholar Rebecca Ann Faulkner paused her career for four years to focus on her family, a decision she believes made her a more effective and empathetic scientist.

Honors for Baserga, Matunis and Tate
Member News

Honors for Baserga, Matunis and Tate

Sept. 9, 2024

Awards, promotions, milestones and more. Find out what's going on in the lives of ASBMB members.

In memoriam: William Catterall
In Memoriam

In memoriam: William Catterall

Sept. 9, 2024

Known as the 鈥渇ather of ion channels,鈥 he was a neuroscientist and pharmacologist at the University of Washington and an ASBMB member for more than 45 years.

Announcing the winners of the 麻豆传媒色情片 Motifs bioart competition
Contest

Announcing the winners of the 麻豆传媒色情片 Motifs bioart competition

Sept. 3, 2024

The 12 winning works of art to be featured in the 2025 ASBMB calendar were selected from 37 entries received from scientists in both academia and industry at all career stages with submissions coming from as far away as Pakistan and Brazil.