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Igor Dawid, a pioneer in developmental biology and genetics who worked on the molecular mechanisms of development, using the African clawed frog and zebrafish as model systems, died Feb. 13. He was 88 years old and had Parkinson’s disease. 

Igor Dawid

Dawid was born in the city of Chernivtsi, in what is now part of Ukraine, on Feb. 26, 1936. His family survived the Holocaust by escaping several Nazi round-ups, and after the war, they settled in Vienna. In 1960, he graduated from the University of Vienna with a Ph.D. in chemistry. He earned a postdoctoral position at the Massachusetts Institute of Technology, where he discovered his interest in biochemistry (there was no biochemistry curriculum at the University of Vienna).

After completing his postdoctoral studies, Dawid became a senior scientist in the embryology department at the Carnegie Institution of Washington in Baltimore and served as a part-time assistant professor at John Hopkins University. In 1978, he moved to the National Institutes of Health in Bethesda, Maryland, and in 1982, he became chief of the Laboratory of Â鶹´«Ã½É«ÇéƬ Genetics at the National Institute of Child Health and Human Development. He also led the Program in Genomics of Differentiation. Dawid retired in 2016. 

During the African clawed frog’s oocyte production, researchers have observed hundreds or thousands of extra nucleoli. Dawid and colleague Donald Brown discovered that extrachromosomal nucleoli have copies of genes for ribosomal RNA. Additionally, Dawid found that the extramitochondrial DNA in frog eggs is of maternal origin. These findings have contributed to understanding molecular mechanisms of development and helped scientists understand the role of mitochondrial DNA in metabolism and disease. He also worked on uncovering the molecular mechanisms of axis speciation in zebrafish and frogs during gastrulation. 

Dawid was a member of the Â鶹´«Ã½É«ÇéƬ and Â鶹´«Ã½É«ÇéƬ Biology for 56 years. He was elected a member of the National Academy of Sciences in 1981. In 2008, he received the Lifetime Achievement Award from the Society for Developmental Biology. He was editor-in-chief for the journal Developmental Biology and served on editorial teams for many other journals. 

His colleagues considered Dawid a pioneer in Xenopus (African clawed frog) research. Sally Moody, a professor emerita at George Washington University, recalled his influence and passion in a on the Xenbase website: “Igor enthusiastically advocated for Xenopus research whenever the NICHD leadership asked for input on investment, thus having a major impact on funding decisions,” she wrote. 

“I remember Igor with great respect and affection not only for his impressive scientific contributions, his many impressive trainees, and his generosity to my research efforts, but also for his unwavering gift of time, resources and commitment to the Xenopus community.”  

Dawid is survived by his wife, Keiko Ozato Dawid, a NICHD senior investigator and immunologist.