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March is Brain Injury Awareness Month, a time to bring public attention to an issue affecting millions of people in the U.S. every year. The Brain Injury Association of America leads this campaign with the purpose of destigmatizing brain injury, empowering those who have survived a brain injury, and promoting the many types of support available.

Many ways to injure your brain

According to the BIAA, a person in the U.S. sustains a brain injury every nine seconds, culminating in more than 3.5 million injuries each year. There are several clinical classifications for brain injuries. Doctors refer to injuries that do not occur at or around the time of birth and are not genetic or degenerative as an acquired brain injury. An ABI can be either a nontraumatic or a traumatic brain injury, depending on the injury’s inciting source.

Nontraumatic brain injuries include:

• infectious disease
• electric shock
• toxic exposure
• metabolic disorders
• neurotoxic poisoning
• lack of oxygen
• drug overdose

Traumatic brain injuries include:

• car and motorcycle accidents
• sports injuries
• abusive head trauma
• gunshot wounds
• workplace injuries

The BIAA also reports that, in the U.S., about 2.8 million people sustain a TBI annually, with  some 280,000 resulting in hospitalizations. Of those injuries, about 50,000 are fatal, meaning there are approximately 155 deaths every day from TBI-related injuries.  One in every 60 people has a TBI-related disability, culminating in around 5.3 million people total.

There are three levels of TBI severity: mild, moderate and severe. Doctors determine the severity of the injury using the , which examines motor response, verbal ability and eye opening —  ranking patient responses with a total score between 3 and 15. A mild TBI lands on the higher side of the scale, whereas a severe TBI results in a lower score.

Risk factors and vulnerable patient populations

Falls are a major cause of brain injury, resulting in 40.5% of all TBIs. This places adolescents, young adults and elderly patients at the highest risk for TBI-related injuries.

, a nonprofit service provider for people with brain and spinal cord injuries, reports that elderly patients (age 65 and older) are at greater risk for hospitalization and death after sustaining a TBI. The Centers for Disease Control and Prevention supports this claim, citing a 17% nationwide increase in fall-related TBI deaths between 2008–2017, occurring most often in people age 75 years or older. 

Men are to suffer a TBI-related injury than women. They are also more likely to become hospitalized or die from their injuries. The BIAA attributes this difference to male involvement in that can cause the injury, affect recovery and increase the risk of recurring injuries. Further, gender differences in societal expectations of self-care after injury and the rate of recovery may potentiate negative patient outcomes for men. The fact that male patients , opting to leave the hospital earlier than recommended after injury, plainly illustrates this phenomenon. 

Current research in TBIs 

TBIs are an active area of study for neuroscience researchers. The emphasizes funding support for laboratories investigating the molecular and clinical factors of TBIs. Below are a few TBI-focused research highlights from Â鶹´«Ã½É«ÇéƬ and Â鶹´«Ã½É«ÇéƬ Biology journals.

: Patients who sustain multiple concussions or a moderate TBI are at risk for a type of dementia that presents at an early age. Scientists are still learning how TBI and dementia are linked on a molecular level. in the Journal of Biological Chemistry identifies a toxic form of a microtubule protein, called tau, in rats’ brains post-TBI. Tau plays a major pathological role in several types of dementia. These findings reveal a potential connecting factor involved in TBI-related dementia and an early-detection marker for patients.

: A TBI can cause brain-cell death and tissue degeneration, potentially leading to many negative clinical symptoms for the patient, depending on the severity of the injury. One therapeutic approach involves targeting the molecular pathway that controls cell death. Calpains are an essential protein that regulates this process, whether silencing calpains minimizes TBI-related brain damage. Their results showed therapeutic promise, with observed reductions in cell death and tissue degeneration when silencing calpain-1. The study was published in JBC.

: Mitochondria are an essential part of cell metabolism — any disruption in their interworking can lead to a host of cell issues. A cellular membrane component called sphingolipids are involved in brain cell signaling, mitochondrial function and cell death. Sphingolipids are rapidly metabolized in the mitochondria by key enzymes, such as neutral ceramidase (NCDase) and sphingosine kinase 2 (SphK2). that TBIs significantly alter sphingolipid metabolism by activating NCDase and suppressing SphK2. Unchecked activation of NCDase leads to an accumulation of sphingosine, leading to mitochondrial dysfunction and cell death. This study, published in JBC, successfully demonstrates how decreasing NCDase activation restores sphingolipid metabolism and decreases TBI-induced damage.   

: The brain relies heavily on a neurotransmitter, called glutamate, as its primary communication “on” switch. Releasing glutamate activates neighboring brain cells, allowing the transmission of important messages throughout the brain. However, too much glutamate causes brain damage through a pathological process called excitotoxicity. Neurological disorders and TBIs can cause cell death by overactivating the glutamatergic system. in JBC demonstrates how stimulating the expression of a neuronal protein called CRMP2 can protect against brain-cell death in excitotoxic conditions.   

: Neurons use glucose as a primary energy source, metabolizing it to power their many functions. When a TBI occurs, it causes neurons to metabolize glucose less, depleting energy levels. In this thematic review in the Journal of Lipid Research, for the use of ketone bodies as an energy replacement because they are a natural energy alternative to glucose. This paper discusses several studies demonstrating improved recovery from a TBI using a ketogenic diet intervention. 

The sphingolipid recycling pathway refers to how the product of sphingolipid catabolism, sphingosine, is recycled into a metabolite called ceramide. As mentioned above, mitochondrial function depends on preventing sphingosine accumulation. focused on an important enzyme in the recycling pathway, acid sphingomyelinase. They found that activating ASM promotes sphingosine accumulation in the mitochondria. Increased sphingosine levels may contribute to functional abnormalities in the first week post-TBI. 

: Scientists are using large-scale biological techniques to understand better the molecular impact of TBI and how this connects to other neurological disorders. in the journal Â鶹´«Ã½É«ÇéƬ & Cellular Proteomics investigates changes in protein expression throughout several brain regions after a brain injury. The researchers found elevated expression of major proteins previously implicated in Parkinson’s disease. A pathological hallmark of Parkinson’s, called alpha-synuclein, may provide a linking component between TBIs and Parkinson’s. These findings provide evidence supporting greater PD risk in TBI patients.